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KMID : 0923620130130060289
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Immune Network
2013 Volume.13 No. 6 p.289 ~ p.294
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Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain
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Jha Mithilesh Kumar
Jeon Sang-Min
Jin Myung-Won
Lee Won-Ha
Suk Kyoung-Ho
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Abstract
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Lipocalin-2 (LCN2) is an acute-phase protein induced by in-jury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface re-ceptor to regulate diverse cellular processes. The role of LCN2 as a chemokine inducer in the central nervous system (CNS) has been previously reported. Based on the previous participation of LCN2 in neuroinflammation, we investigated the role of LCN2 in formalin-induced nociception and patho-logical pain. Formalin-induced nociceptive behaviors (licking/ biting) and spinal microglial activation were significantly re-duced in the second or late phase of the formalin test in Lcn2 knockout mice. Likewise, antibody-mediated neutralization of spinal LCN2 attenuated the mechanical hypersensitivity induced by peripheral nerve injury in mice. Taken together, our results suggest that LCN2 can be therapeutically tar-geted, presumably for both prevention and reversal of acute inflammatory pain as well as pathological pain.
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KEYWORD
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Lipocalin-2, Acute nociception, Pathological pain, Neuroinflammation, Microglia, Spinal cord
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